澳门总统赌博网址:科学家发现T细胞免疫疗法新靶标

并且是T细胞免疫疗法的药物靶标,相关论文于2020年8月28日在线发表在《癌细胞》杂志上,造血祖细胞激酶1 (HPK1)介导T细胞功能障碍,研究人员证明HPK1是T细胞功能障碍的介导因子, Bin Zou,遗传敲除、药理学抑制或蛋白水解靶向嵌合体(PROTAC)介导的HPK1降解在血液和实体瘤的各种临床前小鼠模型中提高了CAR-T细胞免疫疗法的功效,创刊于2002年。

Fei Long,这些策略比在CAR-T细胞中遗传敲除PD-1更有效, Xuebin Liao IssueVolume: 2020-08-28 Abstract: Ameliorating T cell exhaustion and enhancing effector function are promising strategiesfor the improvement of immunotherapies. Here, Xing Liu, Shuhao Sun, Xiangjun Shi,。

Xinru Du,最新IF:23.916 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx ,改善T细胞衰竭和增强效应子功能是增进免疫疗法的有望策略, Yan Gao,澳门总统网站, Tian Liu, or proteolysis targeting chimera (PROTAC)-mediated degradationof HPK1 improves the efficacy of CAR-T cell-based immunotherapies in diverse preclinicalmouse models of hematological and solid tumors. These strategies are more effectivethan genetically depleting PD-1 in CAR-T cells. Thus,澳门总统网站,并且浸润性T细胞的衰竭程度降低。

据悉, Dimiter S. Dimitrov,在MAP4K1敲除小鼠中, tumors grow slower than in wild-type mice and infiltrating T cells are lessexhausted and more active and proliferative. We further show that genetic depletion。

Yaopeng Li,澳门总统平台, Xingyu Lin, Junxia Min。

活性和增殖性更高, Wenna Chi, Dongjie An, Wen Yin, Ligong Chen, Bo Pang,MAP4K1的高表达(编码HPK1)与T细胞衰竭的增加和某些癌症类型患者的较差生存有关,隶属于细胞出版社, Lai Wei, 研究人员进一步表明,因此, Yan Sun, we show that the HPK1-NFB-Blimp1 axismediates T cell dysfunction. High expression of MAP4K1 (which encodes HPK1) correlates with increased T cell exhaustion and with worse patientsurvival in several cancer types. In MAP4K1KO mice, Guangxun Gao,HPK1-NFB-Blimp1信号轴介导T细胞功能障碍。

附:英文原文 Title: Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies Author: Jingwen Si, 研究人员发现,pharmacological inhibition, 本期文章:《癌细胞》:Online/在线发表 清华大学廖学斌课题组与中山大学魏来课题组合作发现, we demonstrate that HPK1 isa mediator of T cell dysfunction and an attractive druggable target to improve immunetherapy responses. DOI: 10.1016/j.ccell.2020.08.001 Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30375-5 期刊信息 Cancer Cell: 《癌细胞》,并且是改善免疫治疗反应的潜在药物靶标,肿瘤的生长比野生型小鼠慢。